This is a low-dose combination medication used to help people with type 2 diabetes control their blood sugar levels. It’s especially useful for starting therapy or for people who need mild glucose control with minimal side effects.

Composition:

• Glimepiride (0.5 mg): A sulfonylurea that stimulates the pancreas to release more insulin.
• Metformin (500 mg): A biguanide that:
  • Reduces glucose production in the liver
  • Improves the body’s insulin sensitivity
  • Slows the absorption of glucose from food

How It Works:

Together, the two medicines:

• Lower fasting and post-meal blood sugar levels
• Work in different ways to improve overall glycemic control

This combination is often used in early stages of type 2 diabetes or for those needing a gentler therapy option.

Who Should Take It:

• Adults with type 2 diabetes
• Patients who are just beginning combination therapy
• Those who need low-dose treatment to avoid hypoglycemia or stomach issues

How to Take:

• Take once or twice daily, with meals
• Swallow the tablet whole with water
• Do not skip meals while taking this medicine to avoid low blood sugar

Benefits:

• Gentle and effective blood sugar control
• Lower chance of side effects due to the low dose
• Helps reduce the risk of complications like nerve damage, kidney damage, and eye problems

Common Side Effects:

• Mild hypoglycemia (low blood sugar) – especially if meals are skipped
• Nausea or upset stomach
• Diarrhea
• Slight weight gain
• Metallic taste (from metformin)

These side effects are typically temporary and lessen as your body adjusts.

Who Should Avoid It:

• Patients with type 1 diabetes
• People with severe kidney or liver problems
• Those with a history of lactic acidosis
• Pregnant or breastfeeding women (unless advised by a doctor)

Alcohol Warning:

Avoid alcohol—it can increase the risk of:

• Lactic acidosis (from metformin)
• Low blood sugar (from glimepiride)

Monitoring Required:

• Regular blood sugar checks
• Periodic kidney and liver function tests
• HbA1c testing every 3–6 months

Q1. What is Glimepiride 0.5 mg + Metformin 500 mg used for?

A: This combination medicine is used to manage type 2 diabetes. It helps control high blood sugar levels in people whose condition cannot be controlled by metformin alone or diet and exercise.

Q2. How does this medicine work?

A:

• Glimepiride helps your pancreas release more insulin.
• Metformin lowers the sugar your liver produces and helps your body use insulin better.
  Together, they provide effective blood sugar control.

Q3. Is this a starter dose for diabetes treatment?

A: Yes. This is a low-dose combination, ideal for early treatment or for people who are sensitive to side effects or need gentle glucose control.

Q4. How should I take this medicine?

A: Take it once or twice daily with food, exactly as your doctor prescribes. Taking it with meals helps reduce the risk of stomach upset and low blood sugar.

Q5. Can this cause low blood sugar (hypoglycemia)?

A: Yes, especially if you skip meals or over-exercise. Symptoms include sweating, shakiness, hunger, and dizziness. Always carry sugar or candy with you.